Recently published health research – relevant and practical info to improve your daily life.
Benefit from high quality studies & latest advice on diet and exercise.
WHAT DOES HIP WHILST SITTING PAIN MEAN?
Hip pain that includes buttock, and thigh pain may result from damage or injury to the muscles, tendons, lumbar discs or ligaments.
New research : One Cup of Leafy Veges Daily Boosts Muscle Function.
EXERCISING MUSCLE COMBATS CHRONIC INFLAMMATION
Biomedical engineers have demonstrated that human muscle has an innate ability to ward off damaging effects of chronic inflammation when exercised.
The new discovery was made possible through the use of lab-grown, engineered human muscle, demonstrating the first-of-its-kind research platform.
“In this case, we discovered that the muscle cells were capable of taking anti-inflammatory actions all on their own”, said Nenad Bursac, professor of biomedical engineering at Duke University.
WHAT IS INFLAMMATION?
Inflammation is not inherently good or bad. When the body is injured, an initial low-level inflammation response clears away debris and helps tissue rebuild.
Other times, the immune system overreacts and creates an inflammatory response that causes damage. And there are diseases that lead to chronic inflammation, such as rheumatoid arthritis and sarcopenia, which can cause muscle to waste away and weaken its ability to contract.
SIMILAR TO ANTI-INFLAMMATORY MEDS
The Duke University researchers have now shown that simulated exercise inhibited a specific molecular pathway in muscle cells. This was similar to two drugs used to treat rheumatoid arthritis, tofacitinib and baricitinib, which block the same pathway.
Both the exercise and the drugs had the same anti-inflammatory effect.
“When exercising, the muscle cells themselves were directly opposing the pro-inflammatory signal induced by interferon gamma, something which we did not expect to happen,” said Bursac.
Zhaowei Chen, Binjie Li, Ren-Zhi Zhan, Lingjun Rao, Nenad Bursac. Exercise Mimetics and JAK Inhibition Attenuate IFN-γ-induced Wasting in Engineered Human Skeletal Muscle. Science Advances, 2021 DOI: 10.1126/sciadv.eabd9502, and